| 1. | MFK Zemplín MichalovceMIC | 0:2 |  FC Spartak TrnavaSPA | so 08.08.202008.08. | 19:00 | | Detail |
| 2. | ŠK Slovan Bratislava SLO | 5:0 | MFK Zemplín MichalovceMIC | ut 11.08.202011.08. | 20:00 | | Detail |
| 3. | FK SenicaSEN | 3:0 | MFK Zemplín MichalovceMIC | so 15.08.202015.08. | 19:00 | | Detail |
| 4. | MFK Zemplín MichalovceMIC | 1:0 |  FC ViOn Zlaté Moravce - VrábleZMO | ut 25.08.202025.08. | 19:00 | | Detail |
| 5. | MŠK ŽilinaMŠK | 6:2 | MFK Zemplín MichalovceMIC | ne 30.08.202030.08. | 19:00 | | Detail |
| 6. | MFK Zemplín MichalovceMIC | 1:1 |  AS TrenčínTRE | so 12.09.202012.09. | 19:00 | | Detail |
| 7. | MFK RužomberokRUŽ | 4:0 | MFK Zemplín MichalovceMIC | so 19.09.202019.09. | 20:00 | | Detail |
| 8. | MFK Zemplín MichalovceMIC | 2:0 |  FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | so 26.09.202026.09. | 19:00 | | Detail |
| 9. | ŠKF ORION TIP SereďSER | 1:1 | MFK Zemplín MichalovceMIC | so 03.10.202003.10. | 19:00 | | Detail |
| 10. | MFK Zemplín MichalovceMIC | 2:4 |  FC DAC 1904 Dunajská StredaDAC | so 17.10.202017.10. | 17:00 | | Detail |
| 11. | FC NitraNIT | 1:1 | MFK Zemplín MichalovceMIC | so 24.10.202024.10. | 17:00 | | Detail |
| 12. | FC Spartak TrnavaSPA | 1:2 | MFK Zemplín MichalovceMIC | so 31.10.202031.10. | 17:00 | | Detail |
| 13. | MFK Zemplín MichalovceMIC | 0:2 | ŠK Slovan Bratislava SLO | so 07.11.202007.11. | 17:00 | | Detail |
| 14. | MFK Zemplín MichalovceMIC | 0:1 | FK SenicaSEN | so 21.11.202021.11. | 14:00 | | Detail |
| 15. | FC ViOn Zlaté Moravce - VrábleZMO | 0:0 | MFK Zemplín MichalovceMIC | so 28.11.202028.11. | 14:00 | | Detail |
| 16. | MFK Zemplín MichalovceMIC | 1:1 | MŠK ŽilinaMŠK | so 05.12.202005.12. | 14:00 | | Detail |
| 17. | AS TrenčínTRE | 2:2 | MFK Zemplín MichalovceMIC | ne 13.12.202013.12. | 14:00 | | Detail |
| 18. | MFK Zemplín MichalovceMIC | 4:3 | MFK RužomberokRUŽ | st 16.12.202016.12. | 14:00 | | Detail |
| 19. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 | MFK Zemplín MichalovceMIC | ne 14.02.202114.02. | 14:00 | | Detail |
| 20. | MFK Zemplín MichalovceMIC | 0:2 | ŠKF ORION TIP SereďSER | so 20.02.202120.02. | 14:00 | | Detail |
| 21. | FC DAC 1904 Dunajská StredaDAC | 2:1 | MFK Zemplín MichalovceMIC | so 27.02.202127.02. | 14:00 | | Detail |
| 22. | MFK Zemplín MichalovceMIC | 1:0 | FC NitraNIT | so 06.03.202106.03. | 14:30 | | Detail |
| Z - 1. | MFK Zemplín MichalovceMIC | 1:1 | FC NitraNIT | so 13.03.202113.03. | 17:00 | | Detail |
| Z - 2. | MFK RužomberokRUŽ | 2:0 | MFK Zemplín MichalovceMIC | so 20.03.202120.03. | 17:00 | | Detail |
| Z - 3. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | so 03.04.202103.04. | 17:00 | | Detail |
| Z - 4. | MFK Zemplín MichalovceMIC | 1:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | so 10.04.202110.04. | 17:00 | | Detail |
| Z - 5. | ŠKF ORION TIP SereďSER | 2:0 | MFK Zemplín MichalovceMIC | so 17.04.202117.04. | 17:00 | | Detail |
| Z - 6. | FK SenicaSEN | 1:1 | MFK Zemplín MichalovceMIC | so 24.04.202124.04. | 17:00 | | Detail |
| Z - 7. | MFK Zemplín MichalovceMIC | 2:1 | MFK RužomberokRUŽ | so 01.05.202101.05. | 17:00 | | Detail |
| Z - 8. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 0:0 | MFK Zemplín MichalovceMIC | so 08.05.202108.05. | 17:00 | | Detail |
| Z - 9. | MFK Zemplín MichalovceMIC | 2:2 | ŠKF ORION TIP SereďSER | so 15.05.202115.05. | 17:00 | | Detail |
| Z - 10. | FC NitraNIT | 0:4 | MFK Zemplín MichalovceMIC | so 22.05.202122.05. | 19:00 | | Detail |
