| 1. | so 24.07.202124.07. | MFK RužomberokRUŽ | 0:0 |  FK SenicaSEN | 90 | 0 | 0 | 52,6% | 72,3% | 47 | 0 |
| 2. | ne 01.08.202101.08. | FK SenicaSEN | 2:1 |  FC Spartak TrnavaSPA | 90 | 0 | 0 | 75,0% | 81,6% | 49 | |
| 3. | pi 06.08.202106.08. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | FK SenicaSEN | 90 | 0 | 0 | 69,2% | 75,4% | 61 | 0 |
| 4. | so 14.08.202114.08. | FK SenicaSEN | 1:1 |  FC DAC 1904 Dunajská StredaDAC | 90 | 0 | 0 | 85,7% | 65,4% | 52 | 0 |
| 5. | ne 22.08.202122.08. | MŠK ŽilinaMŠK | 3:0 | FK SenicaSEN | 90 | 0 | 0 | 60,0% | 68,6% | 35 | 0 |
| 6. | so 28.08.202128.08. | MFK Tatran Liptovský MikulášLMI | 1:2 | FK SenicaSEN | 90 | 0 | 0 | 100,0% | 72,9% | 48 | 0 |
| 7. | so 11.09.202111.09. | FK SenicaSEN | 1:0 |  FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 66,7% | 80,9% | 68 | 0 |
| 8. | so 18.09.202118.09. | AS TrenčínTRE | 3:3 | FK SenicaSEN | 90 | 0 | 0 | 73,7% | 64,5% | 31 | 0 |
| 9. | so 25.09.202125.09. | FK SenicaSEN | 0:3 |  ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 50,0% | 83,3% | 48 | |
| 10. | so 02.10.202102.10. | ŠKF ORION TIP SereďSER | 2:1 | FK SenicaSEN | 52 | 0 | 0 | 63,6% | 80,0% | 15 | |
| 12. | so 23.10.202123.10. | FK SenicaSEN | 0:2 | MFK RužomberokRUŽ | 82 | 0 | 0 | 50,0% | 85,5% | 62 | 0 |
| 13. | pi 29.10.202129.10. | FC Spartak TrnavaSPA | 2:1 | FK SenicaSEN | 90 | 0 | 0 | 50,0% | 79,6% | 54 | 0 |
| 14. | so 06.11.202106.11. | FK SenicaSEN | 1:2 | FC ViOn Zlaté Moravce - VrábleZMO | 90 | 0 | 0 | 57,9% | 78,8% | 33 | 0 |
| 15. | so 20.11.202120.11. | FC DAC 1904 Dunajská StredaDAC | 1:0 | FK SenicaSEN | 78 | 0 | 0 | 30,8% | 63,6% | 22 | 0 |
| 16. | pi 26.11.202126.11. | FK SenicaSEN | 2:2 | MŠK ŽilinaMŠK | 90 | 0 | 0 | 63,2% | 60,5% | 43 | |
| 17. | so 04.12.202104.12. | FK SenicaSEN | 1:0 | MFK Tatran Liptovský MikulášLMI | 90 | 0 | 0 | 58,6% | 71,9% | 64 | |
| 21. | so 19.02.202219.02. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 3:4 | ŠK Slovan Bratislava SLO | 90 | 0 | 0 | 66,7% | 69,7% | 33 | 0 |
| 22. | so 26.02.202226.02. | MFK RužomberokRUŽ | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 68,0% | 63,2% | 57 | 0 |
| - 1. | so 05.03.202205.03. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 0:1 | FC ViOn Zlaté Moravce - VrábleZMO | 40 | 0 | 0 | 66,7% | 80,0% | 25 | 0 |
| - 2. | pi 11.03.202211.03. | AS TrenčínTRE | 2:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 70,0% | 66,7% | 57 | 0 |
| - 3. | so 19.03.202219.03. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 | MFK Tatran Liptovský MikulášLMI | 90 | 0 | 0 | 70,4% | 63,6% | 66 | |
| - 5. | so 09.04.202209.04. | FK SenicaSEN | 2:1 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 61,1% | 71,4% | 56 | |
| - 6. | so 16.04.202216.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:1 | AS TrenčínTRE | 90 | 0 | 0 | 53,8% | 65,1% | 43 | 0 |
| - 7. | so 23.04.202223.04. | MFK Tatran Liptovský MikulášLMI | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 0 | 58,3% | 69,0% | 58 | |
| - 8. | so 30.04.202230.04. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:2 |  MFK Zemplín MichalovceMIC | 82 | 1 | 0 | 91,7% | 78,0% | 59 | 0 |
| - 9. | so 14.05.202214.05. | FC ViOn Zlaté Moravce - VrábleZMO | 1:3 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 90 | 0 | 1 | 61,1% | 73,4% | 64 | 0 |
| - 10. | so 21.05.202221.05. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 1:0 | FK SenicaSEN | 46 | 0 | 0 | 57,1% | 82,1% | 56 | 0 |
