| 2. | so 31.07.202131.07. | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 2:0 |  MFK Zemplín MichalovceMIC | 23 | 0 | 0 | 50,0% | 60,0% | 10 | 0 |
| 3. | so 07.08.202107.08. | MFK Zemplín MichalovceMIC | 1:2 |  AS TrenčínTRE | 14 | 0 | 0 | 50,0% | 60,0% | 5 | 0 |
| 4. | so 14.08.202114.08. | ŠK Slovan Bratislava SLO | 3:1 | MFK Zemplín MichalovceMIC | 18 | 0 | 0 | 62,5% | 57,1% | 7 | 0 |
| 5. | so 21.08.202121.08. | MFK Zemplín MichalovceMIC | 2:1 |  MFK Tatran Liptovský MikulášLMI | 73 | 0 | 1 | 66,7% | 64,0% | 25 | 0 |
| 6. | so 28.08.202128.08. | MFK RužomberokRUŽ | 0:0 | MFK Zemplín MichalovceMIC | 33 | 0 | 0 | 25,0% | 76,9% | 13 | 0 |
| 7. | so 11.09.202111.09. | MFK Zemplín MichalovceMIC | 1:2 |  FC Spartak TrnavaSPA | 8 | 0 | 0 | 40,0% | 100,0% | 5 | 0 |
| 8. | so 18.09.202118.09. | MFK Zemplín MichalovceMIC | 2:1 |  FC ViOn Zlaté Moravce - VrábleZMO | 55 | 0 | 0 | 54,5% | 60,0% | 15 | 0 |
| 9. | so 25.09.202125.09. | ŠKF ORION TIP SereďSER | 0:1 | MFK Zemplín MichalovceMIC | 24 | 1 | 0 | 50,0% | 33,3% | 3 | 0 |
| 10. | so 02.10.202102.10. | MFK Zemplín MichalovceMIC | 1:0 |  MŠK ŽilinaMŠK | 32 | 0 | 0 | 57,1% | 77,8% | 9 | 0 |
| 13. | so 30.10.202130.10. | MFK Zemplín MichalovceMIC | 0:2 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 30 | 0 | 0 | 25,0% | 64,3% | 14 | 0 |
| 14. | pi 05.11.202105.11. | AS TrenčínTRE | 4:2 | MFK Zemplín MichalovceMIC | 46 | 0 | 0 | 42,9% | 60,0% | 10 | 0 |
| 15. | ne 21.11.202121.11. | MFK Zemplín MichalovceMIC | 1:2 | ŠK Slovan Bratislava SLO | 15 | 0 | 0 | 75,0% | 66,7% | 9 | 0 |
| 16. | so 27.11.202127.11. | MFK Tatran Liptovský MikulášLMI | 0:1 | MFK Zemplín MichalovceMIC | 25 | 0 | 0 | 66,7% | 60,0% | 5 | 0 |
| 17. | so 04.12.202104.12. | MFK Zemplín MichalovceMIC | 0:3 | MFK RužomberokRUŽ | 28 | 0 | 0 | 27,3% | 54,5% | 11 | 0 |
| 18. | pi 10.12.202110.12. | FC Spartak TrnavaSPA | 2:0 | MFK Zemplín MichalovceMIC | 75 | 0 | 0 | 15,4% | 80,6% | 31 | 0 |
| 19. | so 18.12.202118.12. | FC ViOn Zlaté Moravce - VrábleZMO | 0:1 | MFK Zemplín MichalovceMIC | 67 | 0 | 0 | 28,6% | 80,8% | 26 | 0 |
| 20. | pi 11.02.202211.02. | MFK Zemplín MichalovceMIC | 0:1 | ŠKF ORION TIP SereďSER | 68 | 0 | 0 | 46,7% | 61,0% | 41 | 0 |
| 21. | so 19.02.202219.02. | MŠK ŽilinaMŠK | 2:1 | MFK Zemplín MichalovceMIC | 72 | 0 | 0 | 34,8% | 56,5% | 23 | 0 |
| - 1. | so 05.03.202205.03. | MFK Zemplín MichalovceMIC | 1:0 | AS TrenčínTRE | 5 | 0 | 0 | 0,0% | 0,0% | 0 | |
| - 2. | so 12.03.202212.03. | FK SenicaSEN | 2:1 | MFK Zemplín MichalovceMIC | 22 | 0 | 0 | 33,3% | 22,2% | 9 | 0 |
| - 3. | so 19.03.202219.03. | MFK Zemplín MichalovceMIC | 1:0 | FC ViOn Zlaté Moravce - VrábleZMO | 87 | 0 | 0 | 55,0% | 66,7% | 42 | 0 |
| - 4. | so 02.04.202202.04. | MFK Zemplín MichalovceMIC | 1:0 | FK Pohronie Žiar n.H. Dolná ŽdaňaPOH | 67 | 0 | 0 | 46,2% | 65,4% | 26 | 0 |
| - 5. | pi 08.04.202208.04. | MFK Tatran Liptovský MikulášLMI | 3:1 | MFK Zemplín MichalovceMIC | 82 | 0 | 0 | 55,6% | 64,7% | 34 | 0 |
| - 6. | po 18.04.202218.04. | FC ViOn Zlaté Moravce - VrábleZMO | 1:1 | MFK Zemplín MichalovceMIC | 66 | 0 | 0 | 27,3% | 76,9% | 13 | 0 |
| - 7. | so 23.04.202223.04. | MFK Zemplín MichalovceMIC | 1:0 | FK SenicaSEN | 61 | 0 | 0 | 38,9% | 69,2% | 26 | 0 |
| - 9. | pi 13.05.202213.05. | MFK Zemplín MichalovceMIC | 1:2 | MFK Tatran Liptovský MikulášLMI | 78 | 0 | 0 | 78,6% | 65,0% | 20 | 0 |
